Gastrointestinal bleeding in critically ill immunocompromised patients

Jennifer Catano (1) , Sophie Caroline Sacleux (2) , Jean-Marc Gornet (1) , Marine Camus (3) , Naike Bigé (4) , Faouzi Saliba (2) , Elie Azoulay (1) , Guillaume Dumas (1) , Lara Zafrani (1, 5)

1 AP-HP - Hopital Saint-Louis [AP-HP]
2 Hôpital Paul Brousse
3 CRSA - Centre de Recherche Saint-Antoine
4 CHU Saint-Antoine [AP-HP]
5 HIPI (UMR_S_976 / U976) - Immunologie humaine, physiopathologie & immunothérapie

Background Acute gastrointestinal bleeding (GIB) may be a severe condition in immunocompromised patients and may require intensive care unit (ICU) admission. We aimed to describe the clinical spectrum of critically ill immunocompromised patients with GIB and identify risk factors associated with mortality and severe GIB defined by hemorrhagic shock, hyperlactatemia and/or the transfusion of more than 5 red blood cells units. Finally, we compared this cohort with a control population of non-immunocompromised admitted in ICU for GIB. Results Retrospective study in 3 centers including immunocompromised patients with GIB admitted in ICU from January, 1st 2010 to December, 31rd 2019. Risk factors for mortality and severe GIB were assessed by logistic regression. Immunocompromised patients were matched with a control group of patients admitted in ICU with GIB. A total of 292 patients were analyzed in the study, including 141 immunocompromised patients (compared to a control group of 151 patients). Among immunocompromised patients, upper GIB was more frequent (73%) than lower GIB (27%). By multivariate analysis, severe GIB was associated with male gender (OR 4.48, CI95% 1.75–11.42, p = 0.00), upper GIB (OR 2.88, CI95% 1.11–7.46, p = 0.03) and digestive malignant infiltration (OR 5.85, CI95% 1.45–23.56, p = 0.01). Conversely, proton pump inhibitor treatment before hospitalization was significantly associated with decreased risk of severe GIB (OR 0.25, IC95% 0.10–0.65, p < 0.01). Fifty-four patients (38%) died within 90 days. By multivariate analysis, mortality was associated with hemorrhagic shock (OR 2.91, IC95% 1.33–6.38, p = 0 .01), upper GIB (OR 4.33, CI95% 1.50–12.47, p = 0.01), and long-term corticosteroid therapy before admission (OR 2.98, CI95% 1.32–6.71, p = 0.01). Albuminemia (per 5 g/l increase) was associated with lower mortality (OR 0.54, IC95% 0.35–0.84, p = 0.01). After matching with a control group of non-immunocompromised patients, severity of bleeding was increased in immunocompromised patients, but mortality was not different between the 2 groups. Conclusion Mortality is high in immunocompromised patients with GIB in ICU, especially in patients receiving long term corticosteroids. Mortality of GIB is not different from mortality of non-immunocompromised patients in ICU. The prophylactic administration of proton pump inhibitors should be considered in this population.

Mots clés: Gastrointestinal bleeding; Intensive care unit; Immunocompromised host; Lymphoma

Domaines: Hépatologie et Gastroentérologie; Santé publique et épidémiologie

Jennifer Catano, Sophie Caroline Sacleux, Jean-Marc Gornet, Marine Camus, Naike Bigé, et al.. Gastrointestinal bleeding in critically ill immunocompromised patients. Annals of Intensive Care, 2021, 11, pp.130. ⟨10.1186/s13613-021-00913-6⟩. ⟨hal-03349519⟩