Skip to Main content Skip to Navigation

Prévisualisation

Display 

Licence


Public Domain

Collections

Share

Link

Metrics

Record views

22

Files downloads

368

Indirect Tertiary Alcohol Enantiocontrol by Acylative Organocatalytic Kinetic Resolution

2021

Description : The stereocontrol of tertiary alcohols represents a recurrent challenge in organic synthesis. In the present paper, we describe a simple, efficient, and indirect method to enantioselectively prepare tertiary alcohols through a chiral isothiourea catalyzed selective acylation of adjacent secondary alcohols. This transformation enables the kinetic resolution (KR) of easily prepared racemic diastereoenriched secondary/tertiary diols providing both monoesters and starting diols in highly enantioenriched forms (s-value >200).


https://medihal.archives-ouvertes.fr/hal-03255297
Contributor : Gaelle Chouraqui <>
Submitted on : Wednesday, June 9, 2021 - 2:23:19 PM
Last modification on : Monday, June 14, 2021 - 9:55:32 AM