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Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling

Abstract : Peptides were produced in high yields and, if any, very low epimerization, by mechanochemical coupling of peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term. Ball milling was clearly identified as the key element enabling one to obtain such results.
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https://hal.archives-ouvertes.fr/hal-03228800
Contributor : Thomas-Xavier Métro <>
Submitted on : Tuesday, May 18, 2021 - 1:53:48 PM
Last modification on : Monday, May 31, 2021 - 10:35:25 AM

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Yves Yeboue, Marion Jean, Gilles Subra, Jean Martinez, Frédéric Lamaty, et al.. Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling. Organic Letters, American Chemical Society, 2021, 23 (3), pp.631-635. ⟨10.1021/acs.orglett.0c03209⟩. ⟨hal-03228800⟩

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