Skip to Main content Skip to Navigation
Journal articles

Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index

Abstract : In mice, the plasma concentrations of the appetite-stimulatory and autophagy-inhibitory factor acyl-coenzyme A binding protein (ACBP, also called diazepam-binding inhibitor, DBI) acutely increase in response to starvation, but also do so upon chronic overnutrition leading to obesity. Here, we show that knockout of Acbp/Dbi in adipose tissue is sufficient to prevent high-fat diet-induced weight gain in mice. We investigated ACBP/DBI plasma concentrations in several patient cohorts to discover a similar dual pattern of regulation. In relatively healthy subjects, ACBP/DBI concentrations independently correlated with body mass index (BMI) and age. The association between ACBP/DBI and BMI was lost in subjects that underwent major weight gain in the subsequent 3–9 years, as well as in advanced cancer patients. Voluntary fasting, undernutrition in the context of advanced cancer, as well as chemotherapy were associated with an increase in circulating ACBP/DBI levels. Altogether, these results support the conclusion that ACBP/DBI may play an important role in body mass homeostasis as well as in its failure.
Complete list of metadata

https://hal.sorbonne-universite.fr/hal-03258568
Contributor : Gestionnaire Hal-Su <>
Submitted on : Friday, June 11, 2021 - 3:56:34 PM
Last modification on : Tuesday, July 13, 2021 - 3:27:27 AM

File

s41419-021-03864-9.pdf
Publication funded by an institution

Identifiers

Citation

Adrien Joseph, Hui Chen, Gerasimos Anagnostopoulos, Léa Montégut, Antoine Lafarge, et al.. Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index. Cell Death and Disease, Nature Publishing Group, 2021, 12 (6), pp.599. ⟨10.1038/s41419-021-03864-9⟩. ⟨hal-03258568⟩

Share

Metrics

Record views

37

Files downloads

39